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Rifampicin is a rifamycin antibiotic while isoniazid, pyrazinamide and ethambutol are specific antituberculous agents. Rifamycin and isoniazid are both bactericidal against Mycobacterium tuberculosis. Ethambutol is bacteriostatic against Mycobacterium tuberculosis. Rifampicin and ethambutol also exhibit variable activity against other atypical species of Mycobacterium.
The exact mechanism of action of pyrazinamide is unknown.
